After 40 years of reefkeeping I am impressed with your knowledge of so many inter connected areas of science. You have pulled together an impressive technical paper. Consider this as material for a doctorate theosis.
While I agree with the science, some of your conclusions and some of your applications don't work for me. I have been skimmerless for 20 years with no water changes. I always use activated carbon. With cemical warfare in my mixed garden tanks, I can not test for these compounds econominally. Activated carbon is my proactive insurance to this complex topic. With use of dsb (6" deep of arroggonite 2mm-5mm) over a false bottom, I use bacteria for nutrient recycling and complex food webs. I stir the top inch of this sand bed and feed numerous filter feeders in the 75G display tank with Jaubert Plenumn. My refugium is the classic mud/vegatable filter. I use Calurpa Prolifera which I harvest regularly. Some goes to the fish as nutrient recycling, some goes to my compost bin for nutrient export. I also dehydrate this macro and eat as a salty veggie chip, which is good with beer. Remember, I like complex food webs with multiple nutrient pathways.
My current 75G main tank with 30G mud/macro refugium has been set up for ten years with no water changes. Yes, I vacumn sand as required with is very little. I never disturb the mud filter. It is putrid black and smells sulfide when disturbed. It is crawling with worms and feels spongy to the touch. I frequently stir the top inch of display sandbed and watch the filter feeders extend their tentacles into this marine snow storm. I feed all of my sandbeds heavily. I allow bioindicators to tell me if I am feeding enough.
This is a marvelous hobby. For me it is an addiction. I am well pleased to find a source of knowledge that has a balance of common sense. Great article, keep the dialogue coming. Don't lose the passion.
La bonne temps roulee,