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this is why a 50% weekly water change is not a good practice.
If he keeps hard to kill softies like shrooms and hardy fish, it likely won't bother anything. Just a big fat waste of time. Otherwise yes, you are correct. A 50% water change to a typical reefer is usually only under taken only under emergency conditions because we all know it's
brutal on a lot of LPS and virtually all SPS.
Assuming you have a tank with a large bio load a big water change will cause nutrient levels to go all over the place and stress anything with a hard skeleton. If you aren't using RO water than you are likely dumping mass amounts of phosphate into the tank as well.
My regiment is 10% weekly, with calcium and buffer suppliments between. Also, my main frag tank has NO fish or inverts in it, and I actually add nitrate from my fresh water tank to keep the level at about 5ppm. The extra nitrate helps growth, and doesn't bother my acros in the least.
A few years ago I tried an experiment with a tank that had no water changes for 4 months and using the suppliment only approach. No fish or inverts in the tank so nitrate was zero to start and zero to end. It didn't work. After about a month the tank started to deteriorate and growth eventually slowed to nothing. Then stuff started going backward. I concluded that obviously nutrient export isn't the only reason to do water changes.
There's a lot of theories on this, some rather weird but some make tempting sense. A big belief is that enclosed aquariums become screwed up ionically after awhile because of the constant circulation of water agains't plastic and inert surfaces. In the open ocean you have interaction of waves, rain, and influx of cold water currents from the poles. The addition of freshly mixed water, even a small percentage to a tank simply does more chemically than add trace elements from salt mix.